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Chemical and toxicological studies in clinical laboratory practice [Электронный ресурс] = Химико-токсикологические исследования в работе клинической лаборатории : учебное пособие : manual : Second edition / M.F. Reznichenko [и др.]; edited by Prof. O. V. Ostrovskij ; под редакцией д-ра мед. наук, профессора О. В. Островского ; rev. A. A. Ozerov ; рец. А. А. Озеров ; Federal state budgetary educational institution of нigher education "Volgograd state medical university" of the Ministry of Healthcare of the Russian Federation, Department of fundamental and clinical biochemistry. - 2-е изд. - Volgograd ; Волгоград : Library and Publishing Center of VolgSMU, 2026. - 122 p. (уч.-изд. л. 8,02). - Библиогр.: с. 110-114. - ISBN 978-5-9652-1168-5.

Авторы: Reznichenko M. F., Nesterova A. A., Smirnova L. A., Zykova E. V., Antonov V. A.

Ключевые слова: chemical-toxicological analysis, toxicokinetics, pharmacokinetics, chromatography, spectrophotometry, biosamples, sample preparation, химико-токсикологический анализ, токсикокинетика, фармакокинетика, тонкослойная хроматография, химия на английском языке

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Аннотация: This manual outlines key topics and concepts for class preparation and includes protocols for practical sessions within the course “Chemical and toxicological studies in the clinical laboratory practice”. The manual is intended for international students of medical universities specializing in “Pharmacy”. The content contributes to the development of the following competencies: UC-1.1.3, GPC-1.1.1, GPC-1.2.1, PC-4.1.1 for students of the pharmaceutical faculty. , В настоящем пособии изложены ключевые вопросы и понятия для подготовки к занятиям и приведены прописи практических работ курса «Химико-токсикологические исследования в работе клинической лаборатории». Пособие предназначено для иностранных обучающихся медицинских вузов по специальности «Фармация». Содержание пособия способствует формированию у обучающихся следующих компетенций: УК-1.1.3, ОПК-1.1.1, ОПК-1.2.1, ПК-4.1.1, предназначено для студентов фармацевтического факультета.

Содержание: PREFACE CHAPTER 1. ORGANIZATION OF CHEMICAL?TOXICOLOGICAL RESEARCH IN CLINICAL DIAGNOSTIC LABORATORY. CLASSIFICATION AND CHARACTERISTICS OF TOXIC SUBSTANCES (MODULE 1) 1.1. History of Chemical?Toxicological Research 1.1.1. History of Laboratory Technology Development 1.1.2. First Laboratories., 1.1.3. History of Laboratory Service in Russia 1.1.4. History of Toxicology 1.2. The Main Stages of Laboratory Analysis 1.2.1. Main Terms of Laboratory Quality Control 1.2.2. Processing Laboratory Study Data 1.2.3. Safety Regulations in a Biochemical Laboratory 1.2.4. Organization of Chemical?Toxicological Studies in the Clinical Diagnostic Laboratory 1.3. Classification and Characteristics of Toxic Substances., CHAPTER 2. FUNDAMENTALS OF PHARMACOKINETICS AND TOXICOKINETICS. THERAPEUTIC DRUG MONITORING. METHODS OF ANALYSIS OF TOXIC SUBSTANCES (MODULE 2) 2.1. Basic Concepts and Terms in Toxicology., 2.2. Analytical Methods for the Analysis of Xenobiotics and Toxic Substances in Biological Samples 2.2.1. Preanalytical Stage of Biochemical Analysis: Collection and Preparation of Biomaterial from Laboratory Animals 2.2.2. Preparation of Homogenates from Plants and Animals 2.2.3. High?Performance Liquid Chromatography as a Method for Analyzing Toxic Substances, 2.2.4. Thin Layer Chromatography as a Method of Analysis of Toxic Substances 2.2.5. Application of Spectrophotometric Analysis Methods in Chemical?Toxicological Practice 2.3. Pharmacokinetics and Therapeutic Drug Monitoring 2.4. Methods for Examination of Blood Samples in Toxicology and Forensic Medicine 2.4.1. History of Blood Research 2.4.2. The Shapes (Patterns) of Bloodstains 2.4.3. Detection, Fixation, and Collection of Bloodstains., STUDENT PRACTICAL ASSIGNMENTS Laboratory work 1. Preparation of Tissue Homogenates, Separation of Biological Samples by Centrifugation, and Protein Precipitation Techniques Laboratory Work № 2. Quantitative Determination of Anthracene by High-Performance Liquid Chromatography Laboratory Work № 3. Thin-Layer Chromatography of Anthracene Laboratory Work № 4. Methods of Isolation and Identification of Blood Samples of Various Origins Laboratory., Work № 5. Determination of Carboxyhemoglobin in Blood by Spectrophotometric Method INDEPENDENT STUDY Analysis of Pharmacokinetic Properties of Drugs The answer bank RECOMMENDED READING REFERENCES APPENDIX A Homogenizer Operating Instructions APPENDIX B.